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We studied 24 patients with idiopathic Parkinson's disease in whom electrodes were implanted bilaterally in the subthalamic nucleus under stereotactic guidance with imaging and electrophysiologic testing of the location. After one year of electrical stimulation of the subthalamic nucleus, the patient's scores for activities of daily living and motor examination scores (Unified Parkinson's Disease Rating Scale parts II and III, respectively) off medication improved by 60 percent (P<0.001). Electrical stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease. The severity of symptoms off medication decreases, and the dose of levodopa can be reduced with a consequent reduction in dyskinesias. |
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activities of daily living
disability rating scale,neurological
hematoma,intracerebral
iatrogenic neurologic disorders
intracerebral hemorrhage
neurologic complications of,surgery
Parkinson disease
Parkinson disease,fluctuations in
Parkinson disease,surgical treatment of
review article
spinal cord,blood supply of
stereotaxic surgery
stimulation,deep brain
subthalamic nucleus
subthalamic nucleus deep brain stimulation
treatment of neurologic disorder
tremor,thalamic stimulation for suppression of
Unified Parkinson Rating Scale
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